The Journal of Alternative and Complementary Medicine. June 2007, Vol. 13, Issue 5
13(5): 527-532. doi:10.1089/acm.2007.6316.
Correlated Change in Upper Limb Function and Motor Cortex Activation After Verum and Sham Acupuncture in Patients with Chronic Stroke
To cite this article:
Judith D. Schaechter, Brendan D. Connell, William B. Stason, Ted J. Kaptchuk, David E. Krebs, Eric A. Macklin, Rosa N. Schnyer, Joel Stein, Donna M. Scarborough, Stephen W. Parker, Chris A. McGibbon, and Peter M. Wayne.
Published in Volume: 13 Issue 5: June 29, 2007
Judith D. Schaechter, Ph.D.
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA.
Brendan D. Connell, B.A.
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA.
William B. Stason, M.D.
Harvard School of Public Health, Boston, MA.
Ted J. Kaptchuk, O.M.D.
Osher Institute, Harvard Medical School, Boston, MA.
David E. Krebs, Ph.D.
Massachusetts General Hospital Biomotion Laboratory, Harvard Medical School, Boston, MA.
Eric A. Macklin, Ph.D.
New England Research Institutes, Watertown, MA.
Rosa N. Schnyer, L.Ac.
Osher Institute, Harvard Medical School, Boston, MA.
New England School of Acupuncture, Watertown, MA.
Joel Stein, M.D.
Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Boston, MA.
Donna M. Scarborough, M.S.
Massachusetts General Hospital Biomotion Laboratory, Harvard Medical School, Boston, MA.
Stephen W. Parker, M.D.
Department of Neurology, Massachusetts General Hospital, Boston, MA.
Chris A. McGibbon, Ph.D.
Institute of Biomedical Engineering, University of New Brunswick, Federicton, New Brunswick, Canada.
Peter M. Wayne, Ph.D.
Osher Institute, Harvard Medical School, Boston, MA.
New England School of Acupuncture, Watertown, MA.
ABSTRACT
Background: Acupuncture may improve motor function in patients with chronic hemiparetic stroke, yet the neural mechanisms underlying such an effect are unknown. As part of a sham-controlled, randomized clinical trial testing the efficacy of a 10-week acupuncture protocol in patients with chronic hemiparetic stroke, we examined the relationship between changes in function of the affected upper limb and brain activation using functional magnetic resonance imaging (fMRI).
Methods: Seven (7) chronic hemiparetic stroke patients underwent fMRI and testing of function of the affected upper limb (spasticity and range-of-motion) before and after a 10-week period of verum (N = 4) or sham (N = 3) acupuncture. The correlation between changes in function of the affected upper limb and brain activation after treatment was tested across patients.
Results: We found a significant positive correlation between changes in function of the affected upper limb (spasticity and range of motion) and activation in a region of the ipsilesional motor cortex. Patients treated with verum acupuncture showed a trend toward a greater maximum activation change in this motor cortical area as compared to those treated with sham acupuncture.
Conclusions: Acupuncture may improve function of the affected upper limb in chronic hemiparetic stroke patients by increasing activity in the ipsilesional motor cortex.
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